There are a number of symptoms that effect patients with Adrenomyeloneuropathy (AMN), including:

• Gradual, progressive weakness and stiffness of the legs
• Loss of the ability to coordinate muscle movement
• Weight loss
• Excessive muscle tone
• Difficulty in walking
• Visual defects
• Difficulty in articulating words
• Behavioral changes
• Adrenal insufficiency
• Seizures
• Sexual dysfunction/impotence
• Bladder dysfunction
• Mild peripheral neuropathy
• Nausea

AMN is usually diagnosed in young men, who display weakness and numbness of the limbs and urination or defecation problems.

For doctors to establish proper diagnosis, blood tests must be taken to examin the levels of serum long chain fatty acid. In addition, MRI examination can reveal white matter abnormalities and neuroimaging findings of this disease are very similar to findings of multiple sclerosis.